Journal article
Retinoic Acid-Inducible Gene i Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection
LSU Schwab, R Farrukee, JF Eleouët, MA Rameix-Welti, SL Londrigan, AG Brooks, AC Hurt, C Coch, T Zillinger, G Hartmann, PC Reading
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2022
Abstract
Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Treatment options are limited, and there is urgent need for the development of efficient antivirals. Pattern recognition receptors such as the cytoplasmic helicase retinoic acid-inducible gene (RIG) I can be activated by viral nucleic acids, leading to activation of interferon-stimulated genes and generation of an "antiviral state."In the current study, we activated RIG-I with synthetic RNA agonists (3pRNA) to induce resistance to RSV infection in vitro and in vivo. In vitro, pretreatment of human, mouse, and ferret airway cell lines with RIG-I agonist before RSV exp..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Awarded by German Center for Infectious Diseases
Awarded by Deutsche Forschungsgemeinschaft German Research Foundation
Awarded by Deutsche Forschungsgemeinschaft German Research Foundation (Germany's Excellence Strategy)
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (project grant APP1143154); the Australian Government Department of Health (support to the Melbourne WHO Collaborating Centre for Reference and Research on Influenza); INSERM; Universite de Versailles Saint Quentin en Yvelines; the German Center for Infectious Diseases (grant TTU 07.834_00 to G. H); and the Deutsche Forschungsgemeinschaft German Research Foundation) (project 369799452-TRR237 to G. H. and under Germany's Excellence Strategy-EXC2151-390873048, of which G. H. is a member). Funding to pay the Open Access publication charges for this article was provided by Australia and New Zealand Institutions (CAUL affiliated).